I will admit my own personal tale in hopes that it will be of assistance for you.
I considered myself trans for over 15 years of life. If I wasn't broke at the time I might've even gone with the surgery. I passed every "test" that psychologists hand out to prove you are trans and even socially transitioned for awhile. Hopefully this adds credit to what I am about to say to you.
Transsexually can be caused by a multitude of things. This can be from Neptune aspects involving sexuality (confusion). Dangerously low energies of one's own biological sex (think a severe lack of venus, moon, etc in women). This can come from negative karma from past lives. Or the opposite, very strong energies of the sex you think you are spiritual (This might be why you think your soul is the opposite gender). It even could be an imbalance in the body's physical hormones. Low testosterone levels in men for example can facilitate this. Men who don't exercise or are obese produce more estrogen than active men. It can be any number of these things and many more, but what it is not, is true.
I "cured" the transsexuality in me by removing negative karma from my soul and tapping into my own sexual energies. I naturally started to engage in activities that leaned more towards my actual gender and this created a positive feedback loop. After about a year, the trans feelings were completely gone. No medication, no therapy. It is possible though to be a feminine man or masculine woman and there is nothing wrong with that if your soul naturally aligns that way. But a female soul can't be in a male body and vice versa.
Another reason this is impossible is because the soul takes on the shape of your body. How would your dick work if your soul had a pussy instead? Ever heard of phantom pain syndrome? It's a condition that amputees have where they get actual pain from their missing limbs. Even though the limb is gone, their soul still produces signals to the brain from the missing area. You can't have spiritual genitals of the opposite sex.