Alrighty so I hope y'all are ready for some science. Epiginetics is the methelation and acetylation of genes within the genome. It takes a long time for these genes to be "turned on and off" but if you follow any steady lifestyle for 5+ years your genes will adapt to it. When we spiritually advance we get physically healthier, part of that is just making better decisions for our overall health, maybe excercizing, yoga, eating healthier etc. All these over time will be reflected in your genome. As to the extent to which meditation applies to epiginetics well this can be debated heavily. Scientists find that humans have somewhere around 90% "throwaway" DNA, or DNA that isn't used. How much oft hat has been lost due to spiritual degredation and not using the powers of our souls is up to contestation. If you never eat vegetables the genes used to help you process them will be turned off, similarly so if you never use your spiritual abilities those genes will to be shut off, over time that'll change and until we run a genome scan on someone whose completed the magnum opus we won't know. On to the changing of DNA to make it immortal. One the reasons we die and that our cells aren't immortal is due to the fact that humans don't have infinite telomeres. They exist on the ends of strands of DNA and when cells go through the duplication process, we lose telomeres, when you run completely out, your cell can't reproduce and it truly reaches the end of it's life. through spiritual means or possibly through turning that gene that we haven't found on that can create more telomeres, it is possible you can to some extent live forever. Of course biology is just a fraction of what makes you human per se, so simply having infinite telomeres won't get the job done, spiritual advancement and perfection is what will holistically keep you alive forever.