It's hard to say for certain. One very close relative of mine, one of our South Nodes is conjunct the other person's Pluto, which would seem negative, but it has been a very healthy and positive life-long relationship.
Look to the other aspects in your synastry, chart rulers, Jupiter, and so on, to see the full picture. I'll post the link in case you haven't seen it, it's the bottom section, about the last 1/3 of the page: https://templeofzeus.org/Prediction.php
Sorry I can't be more help here, I actually read this some days ago and didn't reply as I don't have an exact answer, simply because of my personal example given.